Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases.
Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic …

RNA-based oligonucleotide therapeutics are revolutionizing drug development for disease
treatment. This class of therapeutics differ from small molecules and protein therapeutics in …

The treatment measures of malignant carcinomas are most important for human health. In
recent years the use of targeted therapy based on small molecule compounds and identical …

Anti-angiogenesis has been proved to be an effective strategy for the treatment of tumors.
Anti-angiogenic drugs had achieved certain therapeutic effects. However, drug resistance …

Despite the success of drug discovery over the past decades, many potential drug targets
still remain intractable for small molecule modulation. The development of proteolysis …

PARPi have been explored and applied in the treatment of various cancers with remarkable
efficacy, especially BRCA1/2 mutated ovarian, breast, prostate, and pancreatic cancers …

Background Cereblon (CRBN) has emerged as a vital E3 ubiquitin ligase for Proteolysis-
targeting chimera (PROTAC) design. However, few studies focus on the physiological …

Viral infections represent a major threat to human health and the global economy; however,
most of the currently available antiviral drugs are not fully effective in restricting viral …

Targeted protein degradation (TPD) is a promising approach that has the ability to address
disease-causing proteins. Compared to traditional inhibition, proteolysis targeting chimera …

Targeted protein degradation (TPD) is a rapidly growing field in modern drug discovery that
aims to regulate the intracellular levels of proteins by harnessing the cell's innate …