The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-
translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We …

Levels of the tumor suppressor protein p53 are normally quite low due in part to its short half-
life. p53 levels increase in cells exposed to DNA-damaging agents, such as radiation, and …

Apoptosis is one form of physiological or active cell death. The balance between cell
proliferation and cell death or apoptosis not only effects organ growth but also has a …

Dietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of
natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid …

Abstract p53 is involved in several DNA repair pathways. Some of these require the specific
transactivation of p53-dependent genes and others involve direct interactions between the …

A retroviral vector carrying herpes simplex virus thymidine kinase gene was constructed,
and transfected into the ψ2 packaging cells. The replication-defective retrovirus produced by …

Dietary supplementation with folic acid (FA) has been shown to induce opposing effects on
cancer-related outcomes. The mechanism underlying such heterogeneity is unclear. We …

Apoptotic cell death was observed during aggregate culture of the mouse embryonal
carcinoma cell line P19 exposed to all‐trans retinoic acid (tRA). This finding was confirmed …

Cyclin D1 antisense (D1AS)-transfected lung epithelial cell lines were serum deprived and
then analyzed for three hallmarks of apoptosis: appearance of single-strand DNA breaks …

AIMS: To investigate the prevalence of apoptosis in human hepatocellular carcinomas
(HCC) of different types and grades and in liver cell dysplasia, and to test whether the …