Psychiatric disorders are debilitating diseases, affecting> 80 million people worldwide.
There are no causal cures for psychiatric disorders and available therapies only treat the …

Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four
members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all …

Cannabinoid derivatives have shown promising results for treating neuropsychiatric
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …

Since the 1970s, when ATP was identified as a co-transmitter in sympathetic and
parasympathetic nerves, it and its active metabolite adenosine have been considered …

Alcohol binge drinking is on the increase in the young adult population, and consumption
during pregnancy can be deleterious for foetal development. Maternal alcohol consumption …

According to the adenosine hypothesis of schizophrenia, the classically associated
hyperdopaminergic state may be secondary to a loss of function of the adenosinergic …

The majority of neuronal proteins involved in cellular signaling undergo different
posttranslational modifications significantly affecting their functions. One of these …

Alcohol exposure during development produces physical and mental abnormalities in the
foetus that result in long-term molecular adjustments in the brain, which could underlie the …