Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Macrophages act as scavengers, modulating the immune response against pathogens and
maintaining tissue homeostasis. Metabolism governs macrophage differentiation …

Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …

Background Hepatocellular carcinoma (HCC) remains a global challenge due to its high
morbidity and mortality rates as well as poor response to treatment. The communication …

Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in
secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can …

Anti-cancer peptides (ACPs) are a series of short peptides composed of 10–60 amino acids
that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …