[HTML][HTML] Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid …

F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

The lipid basis of cell death and autophagy

Z Lin, F Long, R Kang, DJ Klionsky, M Yang, D Tang - Autophagy, 2024 - Taylor & Francis
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …

[HTML][HTML] Plasmalogens, platelet-activating factor and beyond–Ether lipids in signaling and neurodegeneration

F Dorninger, S Forss-Petter, I Wimmer, J Berger - Neurobiology of disease, 2020 - Elsevier
Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

[HTML][HTML] Bioactive ether lipids: Primordial modulators of cellular signaling

N Rangholia, TM Leisner, SP Holly - Metabolites, 2021 - mdpi.com
The primacy of lipids as essential components of cellular membranes is conserved across
taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are …

[HTML][HTML] Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting

ELH Dakir, C Gajate, F Mollinedo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer
death among men worldwide. While the five-year survival in local and regional prostate …

Lipid metabolism and Calcium signaling in epithelial ovarian cancer

S Kouba, L Ouldamer, C Garcia, D Fontaine… - Cell calcium, 2019 - Elsevier
Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the
fifth leading cause of all cancer-related deaths in women. The majority of patients are …

[HTML][HTML] Unusual Ether Lipids and Branched Chain Fatty Acids in Sea Cucumber (Cucumaria frondosa) Viscera and Their Seasonal Variation

R Abuzaytoun, SM Budge, W Xia, S MacKinnon - Marine Drugs, 2022 - mdpi.com
The sea cucumber, Cucumaria frondosa, is harvested primarily for its muscular bands and
body wall. Development of a nutraceutical product based on lipid recovered from its viscera …

[HTML][HTML] Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects

Y Xi, Z Yani, M Jing, W Yinhang, H Xiaohui… - Biomedicine & …, 2021 - Elsevier
Increasing evidence suggested that cholesterol is an important integrant of cell membranes,
that plays a key role in tumor progression, immune dysregulation, and pathological changes …

[HTML][HTML] CRAC and SK channels: their molecular mechanisms associated with cancer cell development

A Tiffner, V Hopl, I Derler - Cancers, 2022 - mdpi.com
Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

[HTML][HTML] Plasma lipid profile reveals plasmalogens as potential biomarkers for colon cancer screening

AMAP Fernandes, MCF Messias, GHB Duarte… - Metabolites, 2020 - mdpi.com
In this era of precision medicine, there is an increasingly urgent need for highly sensitive
tests for detecting tumors such as colon cancer (CC), a silent disease where the first …