Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic proteins
and organelles, which realizes the metabolic needs of cells and the renewal of organelles …

Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical
role in vascular morphogenesis and homeostasis. Its loss-of-function has been …

Atherosclerosis is a chronic disease comprising intima malfunction and arterial
inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory …

During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called
autophagosomes. The contributions of specific lipids, such as cholesterol, to the membranes …

Atrial fibrillation (AF) is the common arrhythmias. Myocardial fibrosis (MF) is closely related
to atrial remodeling and leads to AF. MF is the main cause of cardiovascular diseases and a …

Background/Aims: Dysfunction of autophagy has been associated with loss of intestinal
homeostasis. Lipopolysaccharide (LPS) from Gram-negative bacteria is known to be a major …

Cardiac hypertrophy, including hypertension and valvular dysfunction, is a pathological
feature of many cardiac diseases that ultimately leads to heart failure. Melatonin confers a …

Macrophages play crucial roles in immune response and atherosclerosis‐related
cardiovascular disease. Recent evidence of macrophage autophagy has demonstrated a …

Insufficient autophagy has been proposed as a mechanism of cellular aging, as this leads to
the accumulation of dysfunctional macromolecules and organelles. Premature vascular …

Atorvastatin has been shown to reduce early brain edema and neuronal death after
subarachnoid hemorrhage, but its mechanism is not clear. In this study, rat models of …