The cell biology of ferroptosis

SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

[HTML][HTML] Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors

C Scarpellini, G Klejborowska, C Lanthier… - Trends in …, 2023 - cell.com
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual Review of …, 2023 - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

[HTML][HTML] Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

[HTML][HTML] MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

VV Phadnis, J Snider, V Varadharajan… - Cell reports, 2023 - cell.com
Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer.
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …

Driving factors of neuronal ferroptosis

J Jacquemyn, I Ralhan, MS Ioannou - Trends in Cell Biology, 2024 - cell.com
Ferroptosis is an oxidative form of iron-dependent cell death characterized by the
accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated …

Redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment

X Yang, X Sun, J Lei, X Shi, S Zhang, C Luo - Chemical Engineering …, 2024 - Elsevier
Ferroptosis has garnered considerable attention benefiting from its remarkable potential in
fighting malignant tumors. Its occurrence largely relies the overwhelming accumulation of …

[HTML][HTML] Deciphering the link: ferroptosis and its role in glioma

H Wang, Y Liu, S Che, X Li, D Tang, S Lv… - Frontiers in …, 2024 - frontiersin.org
Glioma, as the most frequently occurring primary malignancy in the central nervous system,
significantly impacts patients' quality of life and cognitive abilities. Ferroptosis, a newly …

Metal-phenolic nanocatalyst rewires metabolic vulnerability for catalytically amplified ferroptosis

Y Zhu, X Niu, T Wu, J Cheng, J Zou, Y Pan… - Chemical Engineering …, 2024 - Elsevier
Ferroptosis is associated with excessive lipid peroxidation (LPO) accumulation, followed by
membrane fragmentation. Although lipid metabolism is essential for regulating ferroptosis …

“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers

X Yang, X Zhang, Z Yang, L Cheng, X Liu… - … applied materials & …, 2024 - ACS Publications
Imaging-guided photodynamic therapy (PDT) holds great potential for tumor therapy.
However, achieving the synergistic enhancement of the reactive oxygen species (ROS) …