Systems biology of angiogenesis signaling: Computational models and omics

Y Zhang, H Wang, RHM Oliveira… - WIREs mechanisms …, 2022 - Wiley Online Library
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

The contributions of thrombospondin-1 to epilepsy formation

Y Cheng, Y Zhai, Y Yuan, Q Wang, S Li, H Sun - Neuroscience Bulletin, 2024 - Springer
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability
induced by an imbalance between excitatory and inhibitory networks. Abnormal …

Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to …

Y Zhang, AS Popel, H Bazzazi - ACS Pharmacology & …, 2023 - ACS Publications
Angiogenesis is a critical step in tumor growth, development, and invasion. Nascent tumor
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …

Plicosepalus acacia Extract and Its Major Constituents, Methyl Gallate and Quercetin, Potentiate Therapeutic Angiogenesis in Diabetic Hind Limb Ischemia: HPTLC …

AR Abdel-Hamed, ET Mehanna, RM Hazem, JM Badr… - Antioxidants, 2021 - mdpi.com
Plicosepalus acacia (Fam. Loranthaceae) has been reported to possess hypoglycemic,
antioxidant, antimicrobial, and anti-inflammatory effects. Liquid chromatography combined …

Quantitative modeling to understand cell signaling in the tumor microenvironment

M Song, D Li, SZ Makaryan, SD Finley - Current Opinion in Systems …, 2021 - Elsevier
Tumor cells play a central role in multiple processes associated with cancer progression.
They continuously interact with surrounding cells and the extracellular matrix, displaying …

Functional stratification of cancer drugs through integrated network similarity

S Unsal-Beyge, N Tuncbag - NPJ Systems Biology and Applications, 2022 - nature.com
Drugs not only perturb their immediate protein targets but also modulate multiple signaling
pathways. In this study, we explored networks modulated by several drugs across multiple …

VEGFR-Mediated Cytotoxic Activity of Pulicaria undulata Isolated Metabolites: A Biological Evaluation and In Silico Study

SS Elhady, RFA Abdelhameed, SH Zekry, AK Ibrahim… - Life, 2021 - mdpi.com
Natural products play a remarkable role not only in the synthesis, design, and discovery of
new drugs but also as the most prominent source of drugs and bioactive substances. Adding …

Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease

K Patidar, JH Deng, CS Mitchell… - International Journal of …, 2024 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide.
This study's goal was to identify the signaling drivers and pathways that modulate …

Mechanistic characterization of endothelial sprouting mediated by pro‐angiogenic signaling

M Song, SD Finley - Microcirculation, 2022 - Wiley Online Library
Objective We aim to quantitatively characterize the crosstalk between VEGF‐and FGF‐
mediated angiogenic signaling and endothelial sprouting, to gain mechanistic insights and …

Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential

W Liang, B Liang, K Yan, G Zhang, J Zhuo… - Annals of Biomedical …, 2024 - Springer
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic
technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that …