Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
The contributions of thrombospondin-1 to epilepsy formation
Y Cheng, Y Zhai, Y Yuan, Q Wang, S Li, H Sun - Neuroscience Bulletin, 2024 - Springer
Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability
induced by an imbalance between excitatory and inhibitory networks. Abnormal …
induced by an imbalance between excitatory and inhibitory networks. Abnormal …
Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to …
Angiogenesis is a critical step in tumor growth, development, and invasion. Nascent tumor
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
Plicosepalus acacia Extract and Its Major Constituents, Methyl Gallate and Quercetin, Potentiate Therapeutic Angiogenesis in Diabetic Hind Limb Ischemia: HPTLC …
Plicosepalus acacia (Fam. Loranthaceae) has been reported to possess hypoglycemic,
antioxidant, antimicrobial, and anti-inflammatory effects. Liquid chromatography combined …
antioxidant, antimicrobial, and anti-inflammatory effects. Liquid chromatography combined …
Quantitative modeling to understand cell signaling in the tumor microenvironment
Tumor cells play a central role in multiple processes associated with cancer progression.
They continuously interact with surrounding cells and the extracellular matrix, displaying …
They continuously interact with surrounding cells and the extracellular matrix, displaying …
Functional stratification of cancer drugs through integrated network similarity
S Unsal-Beyge, N Tuncbag - NPJ Systems Biology and Applications, 2022 - nature.com
Drugs not only perturb their immediate protein targets but also modulate multiple signaling
pathways. In this study, we explored networks modulated by several drugs across multiple …
pathways. In this study, we explored networks modulated by several drugs across multiple …
VEGFR-Mediated Cytotoxic Activity of Pulicaria undulata Isolated Metabolites: A Biological Evaluation and In Silico Study
Natural products play a remarkable role not only in the synthesis, design, and discovery of
new drugs but also as the most prominent source of drugs and bioactive substances. Adding …
new drugs but also as the most prominent source of drugs and bioactive substances. Adding …
Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease
K Patidar, JH Deng, CS Mitchell… - International Journal of …, 2024 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide.
This study's goal was to identify the signaling drivers and pathways that modulate …
This study's goal was to identify the signaling drivers and pathways that modulate …
Mechanistic characterization of endothelial sprouting mediated by pro‐angiogenic signaling
Objective We aim to quantitatively characterize the crosstalk between VEGF‐and FGF‐
mediated angiogenic signaling and endothelial sprouting, to gain mechanistic insights and …
mediated angiogenic signaling and endothelial sprouting, to gain mechanistic insights and …
Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential
W Liang, B Liang, K Yan, G Zhang, J Zhuo… - Annals of Biomedical …, 2024 - Springer
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic
technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that …
technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that …