Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

▪ Abstract V (D) J recombination is the specialized DNA rearrangement used by cells of the
immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting …

V (D) J recombination proceeds through a series of protein: DNA complexes mediated in
part by the RAG1 and RAG2 proteins. These proteins are responsible for sequence-specific …

Transposons are ubiquitous in prokaryotic and eukaryotic organisms and are major
determinants of genome structure. Transposition—the movement of discrete segments of …

Genomic evolution has been profoundly influenced by DNA transposition, a process
whereby defined DNA segments move freely about the genome. Transposition is mediated …

Tn 5 was one of the first transposons to be identified. As a result of Tn 5's early discovery
and its simple macromolecular requirements for transposition, the Tn 5 system has been a …

DNA synthesis is considered a defining feature in the movement of transposable elements.
In determining the mechanism of piggyBac transposition, an insect transposon that is being …

This chapter is an update of a survey of insertion sequences (ISs) published in 1998.
Researchers have retained the same basic structure: a first section including some key …

▪ Abstract Transposable elements appear quite disparate in their organization and in the
types of genetic rearrangements they promote. In spite of this diversity, retroviruses and …