Uterine fibroids

EA Stewart, SK Laughlin-Tommaso… - Nature reviews Disease …, 2016 - nature.com
Uterine fibroids (also known as leiomyomas or myomas) are common clonal neoplasms of
the uterus. Fibroids have both smooth muscle and fibroblast components, in addition to a …

Role of nuclear progesterone receptor isoforms in uterine pathophysiology

B Patel, S Elguero, S Thakore… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

Uterine fibroid management: from the present to the future

J Donnez, MM Dolmans - Human reproduction update, 2016 - academic.oup.com
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of
benign uterine tumors. Clinical presentations include abnormal bleeding, pelvic masses …

Preoperative medical therapy before surgery for uterine fibroids

A Lethaby, L Puscasiu… - Cochrane Database of …, 2017 - cochranelibrary.com
Background Uterine fibroids occur in up to 40% of women aged over 35 years. Some are
asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include …

The management of uterine leiomyomas

GA Vilos, C Allaire, PY Laberge, N Leyland… - Journal of Obstetrics and …, 2015 - Elsevier
Objectives The aim of this guideline is to provide clinicians with an understanding of the
pathophysiology, prevalence, and clinical significance of myomata and the best evidence …

[HTML][HTML] Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids

J Donnez, R Hudecek, O Donnez, D Matule… - Fertility and sterility, 2015 - Elsevier
Objective To investigate the efficacy and safety of repeated 12-week courses of 5 or 10 mg
daily of ulipristal acetate for intermittent treatment of symptomatic uterine fibroids. Design …

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

FM Reis, LM Coutinho, S Vannuccini… - Human …, 2020 - academic.oup.com
BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in
general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND …

The medical management of abnormal uterine bleeding in reproductive-aged women

LD Bradley, NA Gueye - American journal of Obstetrics and Gynecology, 2016 - Elsevier
In the treatment of women with abnormal uterine bleeding, once a thorough history, physical
examination, and indicated imaging studies are performed and all significant structural …

[HTML][HTML] Long-term medical management of uterine fibroids with ulipristal acetate

J Donnez, O Donnez, D Matule, HJ Ahrendt… - Fertility and sterility, 2016 - Elsevier
Objective To investigate the efficacy and safety of repeated 12-week courses of 5 or 10 mg
daily ulipristal acetate for intermittent treatment of symptomatic uterine fibroids. Design …

[HTML][HTML] Current medical treatment of uterine fibroids

GS Sohn, SH Cho, YM Kim, CH Cho… - Obstetrics & …, 2018 - synapse.koreamed.org
Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common
benign tumors in women. Heavy or prolonged menstrual bleeding, abnormal uterine …