RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

Liquid-like condensates have been thought to be sphere-like. Recently, various
condensates with filamentous morphology have been observed in cells. One such …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

Many mammalian peripheral tissues have circadian clocks,,,; endogenous oscillators that
generate transcriptional rhythms thought to be important for the daily timing of physiological …

Recent findings demonstrate that multiple mRNAs are co-regulated by one or more
sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …