Harnessing the potential of machine learning and artificial intelligence for dementia research
Progress in dementia research has been limited, with substantial gaps in our knowledge of
targets for prevention, mechanisms for disease progression, and disease-modifying …
targets for prevention, mechanisms for disease progression, and disease-modifying …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Erythropoietin re-wires cognition-associated transcriptional networks
M Singh, Y Zhao, VD Gastaldi, SM Wojcik… - Nature …, 2023 - nature.com
Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely
hematopoiesis-independent, but underlying mechanisms and physiological role of brain …
hematopoiesis-independent, but underlying mechanisms and physiological role of brain …
[HTML][HTML] Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in
the brain, but it is unclear how these genes converge into cell-type-specific networks. We …
the brain, but it is unclear how these genes converge into cell-type-specific networks. We …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
S Mansouri, AM Pessoni, A Marroquín-Rivera… - Nature …, 2023 - nature.com
Major depressive disorder (MDD) is one of the most important causes of disability
worldwide. While recent work provides insights into the molecular alterations in the brain of …
worldwide. While recent work provides insights into the molecular alterations in the brain of …
[HTML][HTML] Postsynaptic autism spectrum disorder genes and synaptic dysfunction
P Bonsi, A De Jaco, L Fasano, P Gubellini - Neurobiology of disease, 2022 - Elsevier
This review provides an overview of the synaptic dysfunction of neuronal circuits and the
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …
Exome-wide association study of treatment-resistant depression suggests novel treatment targets
SB Shah, TN Peddada, C Song, M Mensah, H Sung… - Scientific Reports, 2023 - nature.com
Abstract Treatment-resistant depression (TRD) is a severe form of major depressive disorder
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
Transcriptional cartography integrates multiscale biology of the human cortex
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible …
understand human cortical organization are challenged by reliance on incompatible …
[HTML][HTML] Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease
E Miyoshi, S Morabito, CM Henningfield… - BioRxiv, 2023 - ncbi.nlm.nih.gov
The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable
factors, with remarkable differences evident between individuals at the molecular level. Here …
factors, with remarkable differences evident between individuals at the molecular level. Here …