Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward

M Kopczynska, B Sharif, S Cleaver, N Spencer… - Medicine, 2018 - journals.lww.com
Controversy exists regarding the best diagnostic and screening tool for sepsis outside the
intensive care unit (ICU). Sequential organ failure assessment (SOFA) score has been …

Similar metabolic, innate immunity, and adipokine profiles in adult and pediatric sepsis versus systemic inflammatory response syndrome—a pilot study

T Tavladaki, AM Spanaki, H Dimitriou… - Pediatric Critical Care …, 2017 - journals.lww.com
Objectives: To examine whether the septic profiles of heat shock protein 72, heat shock
protein 90α, resistin, adiponectin, oxygen consumption, CO 2 production, energy …

Optimizing the first response to sepsis: An electronic health record-based Markov decision process model

E Rosenstrom, S Meshkinfam, JS Ivy… - Decision …, 2022 - pubsonline.informs.org
Sepsis is considered a medical emergency where delays in initial treatment are associated
with increased morbidity and mortality, yet there is no gold standard for identifying sepsis …

The new sepsis definitions: implications for critical care practitioners

RM Kleinpell, CA Schorr, RA Balk - American Journal of Critical Care, 2016 - AACN
Sepsis and septic shock are common, patho-physiologically complex, clinical conditions that
are associated with high morbidity, mortality, and cost of care. 1 Sepsis occurs in response …

Paramedic recognition of sepsis in the prehospital setting: a prospective observational study

RS Green, AH Travers, E Cain… - Emergency medicine …, 2016 - Wiley Online Library
Background. Patients with sepsis benefit from early diagnosis and treatment. Accurate
paramedic recognition of sepsis is important to initiate care promptly for patients who arrive …

[HTML][HTML] Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002

Z Zhang, Y Hong, NJ Smischney, HP Kuo… - Journal of thoracic …, 2017 - ncbi.nlm.nih.gov
Severe sepsis and septic shock are major causes of morbidity and mortality in patients
entering the emergency department (ED) or intensive care unit (ICU). Despite substantial …

TIM-3 genetic variants are associated with altered clinical outcome and susceptibility to gram-positive infections in patients with sepsis

C Mewes, T Alexander, B Büttner, J Hinz… - International Journal of …, 2020 - mdpi.com
Background: Previous studies have reported the fundamental role of immunoregulatory
proteins in the clinical phenotype and outcome of sepsis. This study investigated two …

Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis

DJ Kealy, JC Wilson, T Jaconelli, K Hogg… - Journal of leukocyte …, 2024 - academic.oup.com
We report on a pilot study exploring whether blood immune signatures can reveal early
specific indicator profiles for patients meeting sepsis criteria upon hospital admission. We …

Prognostic performance of pancreatic stone protein in critically ill patients with sepsis

L Garcia de Guadiana-Romualdo… - Biomarkers in …, 2019 - Taylor & Francis
Aim: To assess the prognostic value for 28-day mortality of PSP in critically ill patients with
sepsis. Material & methods: 122 consecutive patients with sepsis were enrolled in this study …

Blood calprotectin as a biomarker for infection and sepsis–the prospective CASCADE trial

E Diehl-Wiesenecker, N Galtung, J Dickescheid… - BMC Infectious …, 2024 - Springer
Background Early in the host-response to infection, neutrophils release calprotectin,
triggering several immune signalling cascades. In acute infection management, identifying …