Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

N Xia, S Strand, F Schlufter, D Siuda, G Reifenberg… - Nitric Oxide, 2013 - Elsevier
Many of the cardiovascular protective effects of resveratrol are attributable to an enhanced
production of nitric oxide (NO) by the endothelial NO synthase (eNOS). Resveratrol has …

Polyphenols in dementia: From molecular basis to clinical trials

S Molino, M Dossena, D Buonocore, F Ferrari… - Life sciences, 2016 - Elsevier
Dementia is common in the elderly, but there are currently no effective therapies available to
prevent or treat this syndrome. In the last decade, polyphenols (particularly curcumin …

A mitochondrial nanoguard modulates redox homeostasis and bioenergy metabolism in diabetic peripheral neuropathy

Y Yao, X Lei, Y Wang, G Zhang, H Huang, Y Zhao… - ACS …, 2023 - ACS Publications
As a major late complication of diabetes, diabetic peripheral neuropathy (DPN) is the
primary reason for amputation. Nevertheless, there are no wonder drugs available …

Mitochondria “THE” target of myocardial conditioning

K Boengler, G Lochnit, R Schulz - American Journal of …, 2018 - journals.physiology.org
Several interventions, such as ischemic preconditioning, remote pre/perconditioning, or
postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury …

Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism

A Carrizzo, A Puca, A Damato, M Marino, E Franco… - …, 2013 - Am Heart Assoc
Epidemiological studies have demonstrated that the Mediterranean diet, which is rich in
resveratrol, is associated with a significantly reduced risk of cardiovascular disease …

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature

S Ghaffari, N Roshanravan - Food research international, 2020 - Elsevier
Hypertension (HTN) is a worldwide epidemic in both developed and developing countries. It
is one of the leading causes of major health problems such as cardiovascular disease …

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

KT Murphy - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass associated with significant functional impairment. In addition to a loss of …

Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI)

G Xu, X Zhao, J Fu, X Wang - Annals of palliative medicine, 2019 - apm.amegroups.org
Background: Oxidative stress is one of the main factors that increases reperfusion injury in
the diabetic heart. Resveratrol could decrease oxidation and promote antioxidant factor …

Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect

N Ansari, F Khodagholi - Current neuropharmacology, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no
curative or preventive therapy. Histopathological hallmarks of AD include deposition of β …

Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms

RG Britton, C Kovoor, K Brown - … of the New York Academy of …, 2015 - Wiley Online Library
To truly understand the mechanisms through which resveratrol exerts its biological effects,
the key direct interactions between resveratrol and its target biomolecules must be identified …