Pathogenic role of fibrinogen in the neuropathology of multiple sclerosis: a tale of sorrows and fears

M Alruwaili, HM Al-Kuraishy, A Alexiou… - Neurochemical …, 2023 - Springer
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the
central nervous system (CNS) due to injury of the myelin sheath by immune cells. The …

Smouldering lesion in MS: Microglia, lymphocytes and pathobiochemical mechanisms

D Pukoli, L Vécsei - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

X Shi, T Wei, Y Hu, M Wang, Y Tang - Journal of Neuroinflammation, 2022 - Springer
Background Triggering receptor expressed on myeloid cell 1 (Trem1) is an important
regulator of cellular inflammatory responses. Neuroinflammation is a common thread across …

Gut-microbiota, and multiple sclerosis: background, evidence, and perspectives

C Altieri, B Speranza, MR Corbo, M Sinigaglia… - Nutrients, 2023 - mdpi.com
Many scientific studies reveal a significant connection between human intestinal microbiota,
eating habits, and the development of chronic-degenerative diseases; therefore, alterations …

miRNA involvement in cerebral ischemia-reperfusion injury

MA Neag, AO Mitre, CC Burlacu, AI Inceu… - Frontiers in …, 2022 - frontiersin.org
Cerebral ischemia reperfusion injury is a debilitating medical condition, currently with only a
limited amount of therapies aimed at protecting the cerebral parenchyma. Micro RNAs …

The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use

D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

Tunable surface charge enables the electrostatic adsorption-controlled release of neuroprotective peptides from a hydrogel–nanoparticle drug delivery system

E Ho, Y Deng, D Akbar, K Da… - … Applied Materials & …, 2022 - ACS Publications
We exploit the electrostatic interactions between the positively charged neuroprotective
peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), and negatively charged …

Chronic prostatitis and pelvic pain syndrome: another autoimmune disease?

L Chen, M Zhang, C Liang - Archivum Immunologiae et Therapiae …, 2021 - Springer
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), characterized by chronic pain
in the perineum or lower abdomen regions, is a frequent disorder in men. Previous studies …

Regulation of stress granule formation in human oligodendrocytes

F Pernin, QL Cui, A Mohammadnia… - Nature …, 2024 - nature.com
Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple
sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs …

Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination

R Chunder, A Weier, H Mäurer… - Proceedings of the …, 2022 - National Acad Sciences
Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease of the central nervous
system (CNS) with a high socioeconomic relevance. The pathophysiology of MS, which is …