Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Many physiological changes occur with aging. These changes often, directly or indirectly,
result in a deterioration of the quality of life and even in a shortening of life expectancy …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this
process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle …

Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …