Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …

Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive
inflammation, and support tissue repair processes. Therefore, Treg cells are currently …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …

Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity
of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …