Although distinct human induced pluripotent stem cell (hiPSC) lines can display
considerable epigenetic variation, it has been unclear whether such variability impacts their …

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that
regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a …

The recent derivation of human trophoblast stem cells (TSCs) from placental
cytotrophoblasts and blastocysts opened opportunities for studying the development and …

Activin/Nodal growth factors control a broad range of biological processes, including early
cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an …

Studies using high-resolution genome-wide approaches have recently reported that
genomic and epigenomic alterations frequently accumulate in human pluripotent cells …

Epigenetic reprogramming is a critical event in the generation of induced pluripotent stem
cells (iPSCs). Here, we determined the DNA methylation profiles of 22 human iPSC lines …

The recent development of prime editing (PE) genome engineering technologies has the
potential to significantly simplify the generation of human pluripotent stem cell (hPSC)-based …

Summary Niemann-Pick type C (NPC) disease is a fatal inherited lipid storage disorder
causing severe neurodegeneration and liver dysfunction with only limited treatment options …

Induction of pluripotency by transcription factors has become a commonplace method to
produce pluripotent stem cells. Great strides have been made in our understanding of the …