Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity
W Yi, D Schlueter, X Wang - Brain, Behavior, and Immunity, 2019 - Elsevier
Neuropathology in the human autoimmune disease multiple sclerosis (MS) is considered to
be mediated by autoreactive leukocytes, such as T cells, B cells, and macrophages …
be mediated by autoreactive leukocytes, such as T cells, B cells, and macrophages …
Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
O Uriarte Huarte, D Kyriakis, T Heurtaux… - Frontiers in …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial …
Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria‐related pathways in colorectal cancer
A Everest‐Dass, S Nersisyan, H Maar… - Molecular …, 2024 - Wiley Online Library
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we
illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly …
illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly …
Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy
The interaction of tumor cells with the extracellular matrix (ECM) may affect the rate of cancer
progression and metastasis. One of the major components of ECM are laminins, the …
progression and metastasis. One of the major components of ECM are laminins, the …
LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer
Specificity of RNAi to selected target is challenged by off-target effects, both canonical and
non-canonical. Notably, more than half of all human microRNAs are co-expressed with …
non-canonical. Notably, more than half of all human microRNAs are co-expressed with …
Incautious design of shRNAs for stable overexpression of miRNAs could result in generation of undesired isomiRs
D Maltseva, I Kirillov, A Zhiyanov, D Averinskaya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract shRNA-mediated strategy of miRNA overexpression based on RNA Polymerase
(Pol III) expression cassettes is widely used for miRNA functional studies. For some miRNAs …
(Pol III) expression cassettes is widely used for miRNA functional studies. For some miRNAs …
Effects of laminins 332 and 411 on the epithelial—mesenchymal status of colorectal cancer cells
DV Mal'tseva, YA Makarova, MP Raigorodskaya… - Bulletin of Experimental …, 2019 - Springer
The effects of laminins 332 and 411 (LM-332 and LM-411) on the epithelial—mesenchymal
transformation of colorectal cancer cells (lines HT-29, HCT-116, and RKO) with different …
transformation of colorectal cancer cells (lines HT-29, HCT-116, and RKO) with different …
Connexin 43 controls the astrocyte immunoregulatory phenotype
Astrocytes are the most abundant glial cells of the central nervous system and have recently
been recognized as crucial in the regulation of brain immunity. In most neuropathological …
been recognized as crucial in the regulation of brain immunity. In most neuropathological …
Epithelial to mesenchymal transition marker in 2D and 3D colon cancer cell cultures in the presence of laminin 332 and 411
DV Maltseva, JA Makarova, AY Khristichenko… - Molecular Biology, 2019 - Springer
The loss of apical-basal cell polarity is a necessary stage of the epithelial-mesenchymal
transition (EMT). Polarized epithelial cells interact with the basement membrane (BM) and …
transition (EMT). Polarized epithelial cells interact with the basement membrane (BM) and …
Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
AA Poloznikov, SV Nikulin, DM Hushpulian… - Antioxidants, 2022 - mdpi.com
To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and
“branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF …
“branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF …