We have applied an automated real‐time quantitative PCR assay using a double‐labeled
fluorogenic probe to detect t (9; 22)‐positive cells in haematological malignancies. The …

For more than 30 yrs allogeneic hematopoietic stem cell transplantations have been
successfully performed in patients with hematologic malignancies and bone marrow aplasia …

During the past 2 decades, there has been considerable progress in the treatment of both
childhood and adult acute lymphocytic leukemia (ALL). Currently, 70% to 90% of adults …

In many ways, chronic myeloid leukaemia (CML) serves as a paradigm for the utility of
molecular methods in the diagnosis of malignancy or for monitoring the response of the …

Molecular monitoring of the BCR-ABL transcript in chronic myelogenous leukemia (CML)
using quantitative RT-PCR provides clinicians with important diagnostic and prognostic …

We established a quantitative real-time RT-PCR assay for the detection of chimeric BCR-
ABL transcripts in archival formalin-fixed bone marrow trephines, both acrylate-embedded …

Kinetics of BCR-ABL transcript elimination and its prognostic implications on relapse were
analyzed in patients with chronic myeloid leukemia (CML) after reduced intensity …

In this volume, an international team of experts in chronic myeloid leukemia share their
expertise. In particular, they contribute their insights on the latest advances in understanding …

Recently, a polymorphic base in exon 13 of the BCR gene (exon b2 of the major breakpoint
cluster region) has been identified in the eighth position before the junctional region of BCR …

A leucemia mielóide crônica (LMC) representa 15% das leucemias e apresenta três fases:
crônica, acelerada e crise blástica. A partir da análise citogenética, pode ser identificado o …