The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Occupational noise: auditory and non-auditory consequences

A Sheppard, M Ralli, A Gilardi, R Salvi - International journal of …, 2020 - mdpi.com
Occupational noise exposure accounts for approximately 16% of all disabling hearing
losses, but the true value and societal costs may be grossly underestimated because current …

Middle ear muscle reflex and word recognition in “normal-hearing” adults: evidence for cochlear synaptopathy?

AM Mepani, SA Kirk, KE Hancock, K Bennett… - Ear and …, 2020 - journals.lww.com
Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is
caused by loss of sensory cells; however, animal studies show that hair cell loss is often …

Hidden hearing loss: a disorder with multiple etiologies and mechanisms

DC Kohrman, G Wan… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to
affect auditory neural processing and hearing acuity in subjects with normal audiometric …

Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …

Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: A review of the literature

CG Le Prell - International journal of audiology, 2019 - Taylor & Francis
Objective: Short-term noise exposure that induces transient changes in thresholds has
induced permanent cochlear synaptopathy in multiple species. Here, the literature was …

Working memory and extended high-frequency hearing in adults: Diagnostic predictors of speech-in-noise perception

I Yeend, EF Beach, M Sharma - Ear and Hearing, 2019 - journals.lww.com
Objective: The purpose of this study was to identify the main factors that differentiate
listeners with clinically normal or “near-normal” hearing with regard to their speech-in-noise …

Alterations in auditory brain stem response distinguish occasional and constant tinnitus

NK Edvall, G Mehraei, M Claeson… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND The heterogeneity of tinnitus is thought to underlie the lack of objective
diagnostic measures. METHODS Longitudinal data from 20,349 participants of the Swedish …

[HTML][HTML] Associations between speech recognition at high levels, the middle ear muscle reflex and noise exposure in individuals with normal audiograms

J Shehorn, O Strelcyk, P Zahorik - Hearing Research, 2020 - Elsevier
It has been hypothesized that noise-induced cochlear synaptopathy in humans may result in
functional deficits such as a weakened middle ear muscle reflex (MEMR) and degraded …

[HTML][HTML] Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric …

S Couth, G Prendergast, H Guest, KJ Munro, DR Moore… - Hearing research, 2020 - Elsevier
Musicians are at risk of hearing loss due to prolonged noise exposure, but they may also be
at risk of early sub-clinical hearing damage, such as cochlear synaptopathy. In the current …