Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

Although the discovery and characterization of multiple tumor antigens have sparked the
development of many antigen/derived cancer vaccines, many are poorly immunogenic and …

Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …

Central nervous system (CNS) metastases are a major cause of death in patients with
cancer. Tumor cells must survive during their migration and dissemination in various sites …

Random mutations leading to loss of cell cycle control is not a rare occurrence in an
organism but the mutated cells are recognized and eliminated preventing the development …

Malignant pleural mesothelioma (MPM) is an aggressive tumor with no effective therapy.
However PD-L1/PD-1 immunity checkpoint therapies gave encouraging results; TLR3 is a …

The immune response is a key factor in the fight against HPV infection and related cancers,
and thus, HPV is able to promote immune evasion through the expression of oncogenes. In …

The discovery of a targeted therapeutic compound along with its companion predictive
biomarker is a major goal of clinical development for a personalized anticancer therapy to …

Compelling evidence indicates that radiotherapy (RT) has a systemic inhibitory effect on
nonirradiated lesions (abscopal effect) in addition to the ablation of irradiated tumors …