[HTML][HTML] Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production

Z Yang, Y Huo, S Zhou, J Guo, X Ma, T Li, C Fan… - Cell Metabolism, 2022 - cell.com
A hostile microenvironment in tumor tissues disrupts endoplasmic reticulum homeostasis
and induces the unfolded protein response (UPR). A chronic UPR in both cancer cells and …

[HTML][HTML] Extracellular vesicles: new classification and tumor immunosuppression

M Sheta, EA Taha, Y Lu, T Eguchi - Biology, 2023 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

[HTML][HTML] The crosstalk: Exosomes and lipid metabolism

W Wang, N Zhu, T Yan, YN Shi, J Chen… - Cell Communication and …, 2020 - Springer
Exosomes have been considered as novel and potent vehicles of intercellular
communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and …

Engineering extracellular vesicles restore the impaired cellular uptake and attenuate intervertebral disc degeneration

Z Liao, H Liu, L Ma, J Lei, B Tong, G Li, W Ke, K Wang… - ACS …, 2021 - ACS Publications
Extracellular vesicles (EVs) are potential alternatives for mesenchymal stem cells (MSCs) in
the treatment of musculoskeletal degenerative diseases, including intervertebral disc …

Internalization of exosomes through receptor-mediated endocytosis

A Gonda, J Kabagwira, GN Senthil, NR Wall - Molecular Cancer Research, 2019 - AACR
The tumor microenvironment is replete with factors secreted and internalized by surrounding
cells. Exosomes are nano-sized, protein-embedded, membrane-bound vesicles that are …

Apoptotic bodies for advanced drug delivery and therapy

M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

[HTML][HTML] Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

X Zhao, D Wu, X Ma, J Wang, W Hou… - Biomedicine & …, 2020 - Elsevier
With the development of biomedicine, exosomes are rapidly developing as a new therapy
for tumors. As biological carriers, exosomes possess biological activity and can transport …

[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

B Mathew, S Ravindran, X Liu, L Torres… - Biomaterials, 2019 - Elsevier
Retinal ischemia is a major cause of vision loss and impairment and a common underlying
mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central …