A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

OG de Jong, DE Murphy, I Mäger, E Willms… - Nature …, 2020 - nature.com
Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of
biological cargo, including RNA, that plays a pivotal role in physiological and pathological …

Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system

J Rezaie, V Nejati, M Mahmoodi, M Ahmadi - Biochemical Pharmacology, 2022 - Elsevier
An ideal drug delivery system should selectively deliver incorporated therapeutics to the
target site, escape from immune cells recognition and degradation, and act controlled …

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

C Gong, X Yu, B You, Y Wu, R Wang, L Han… - Journal of …, 2020 - Springer
Cell membrane-covered drug-delivery nanoplatforms have been garnering attention
because of their enhanced bio-interfacing capabilities that originate from source cells. In this …

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

Y Li, Y Gao, C Gong, Z Wang, Q Xia, F Gu, C Hu… - … , Biology and Medicine, 2018 - Elsevier
Exosomes have emerged as a promising drug carrier with low immunogenicity, high
biocompatibility and delivery efficiency. Here in, we isolated exosomes from A33-positive …

The role of extracellular vesicles in viral infection and transmission

L Urbanelli, S Buratta, B Tancini, K Sagini, F Delo… - Vaccines, 2019 - mdpi.com
Extracellular vesicles (EVs) have been found to be released by any type of cell and can be
retrieved in every circulating body fluid, namely blood (plasma, serum), saliva, milk, and …

Biology and role of extracellular vesicles (EVs) in the pathogenesis of thrombosis

M Zarà, GF Guidetti, M Camera, I Canobbio… - International journal of …, 2019 - mdpi.com
Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication.
EVs can be released by every cell type and they can be classified into three major groups …

[HTML][HTML] Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

SAA Kooijmans, OG de Jong, RM Schiffelers - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins,
nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another …

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

A D'Souza, A Burch, KM Dave, A Sreeram… - Journal of Controlled …, 2021 - Elsevier
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …

Extracellular vesicle transportation and uptake by recipient cells: A critical process to regulate human diseases

ZH Kwok, C Wang, Y Jin - Processes, 2021 - mdpi.com
Emerging evidence highlights the relevance of extracellular vesicles (EVs) in modulating
human diseases including but not limited to cancer, inflammation, and neurological …

Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment

K Feng, X Xie, J Yuan, L Gong, Z Zhu… - Journal of …, 2021 - Wiley Online Library
Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs) possess a great
therapeutical potential for osteoarthritis (OA) treatment. However, the steric and electrostatic …