Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

In the last decades, the development of new technologies applied to lipidomics has
revitalized the analysis of lipid profile alterations and the understanding of the underlying …

Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for
cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of …

Growing evidence has highlighted the immune response as an important feature of
carcinogenesis and therapeutic efficacy in clear cell renal cell carcinoma (ccRCC). This …

Transmitochondrial cybrids and multiple OMICs approaches were used to understand
mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple …

Simple Summary Cancer cells directly control nutrient uptake and utilization in a different
manner from that of normal cells. These metabolic changes drive growth, proliferation of …

The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is
not well understood. Here, we investigated how the LCFA transporter CD36 regulates this …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target
in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in …