Studies on HIV virology and pathogenesis address the complex mechanisms that result in
the HIV infection of the cell and destruction of the immune system. These studies are …

The development of small‐molecule modulators of protein–protein interactions is a
formidable goal, albeit one that possesses significant potential for the discovery of novel …

Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …

The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunity,,. All
TLRs use the adaptor MyD88 for signalling, but the mechanisms underlying the MyD88 …

Human immunoglobulin transgenic mice provide a method of obtaining human monoclonal
antibodies (Mabs) using conventional hybridoma technology. We describe a novel strain of …

We analyzed CD4 major histocompatibility complex (MHC) class II interactions with CD4
and lymphocyte activation gene (LAG)‐3 recombinant fusion proteins termed CD4Ig and …

We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and
CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio …

The rate at which HIV-1 infected individuals progress to AIDS is highly variable and
impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 …

CD45 (lymphocyte common antigen) is a receptor‐linked protein tyrosine phosphatase that
is expressed on all leucocytes, and which plays a crucial role in the function of these cells …

Abstract αβ T lymphocytes are able to detect even a single peptide–major histocompatibility
complex (MHC) on the surface of an antigen-presenting cell,. This is despite clear evidence …