Can We Improve Diosmetin Activity? The State-of-the-Art and Promising Research Directions

M Wujec, M Feldo - Molecules, 2023 - mdpi.com
Diosmetin is a natural substance widely distributed in nature, with documented
multidirectional biological effects. The wide spectrum of biological activity of diosmetin gives …

[HTML][HTML] Plant-derived bioactive compounds and their novel role in central nervous system disorder treatment via ATF4 targeting: A systematic literature review

N Zhang, S Zhang, X Dong - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Central nervous system (CNS) disorders exhibit exceedingly intricate pathogenic
mechanisms. Pragmatic and effective solutions remain elusive, significantly compromising …

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

Y Xue, Y Liao, H Wang, S Li, Z Gu… - Journal of the …, 2023 - Wiley Online Library
BACKGROUND Astaxanthin is a type of food‐derived active ingredient with antioxidant,
antidiabetic and non‐toxicity functions, but its poor solubility and low bioavailability hinder …

Enhanced oral bioavailability of capsaicin‐loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation

Y Zhu, S Li, H Wang, M Adu‐Frimpong… - … & Drug Disposition, 2023 - Wiley Online Library
The purpose of this work was to fabricate the microencapsulation of capsaicin using
electrospray technology and polyvinylpyrrolidone (PVP) K30 as a carrier. The morphological …

Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression

W Raza, A Meena, S Luqman - Molecular Carcinogenesis, 2024 - Wiley Online Library
Flavonoids, constituting the most extensive category of polyphenols, founds in a variety of
plants and comprise over 9000 compounds. Diosmetin, O‐methylated flavone (3', 5, 7 …

Anti-Inflammatory Properties of the Citrus Flavonoid Diosmetin: An Updated Review of Experimental Models

Y Fang, W Xiang, J Cui, B Jiao, X Su - Molecules, 2024 - mdpi.com
Inflammation is an essential contributor to various human diseases. Diosmetin (3′, 5, 7-
trihydroxy-4′-methoxyflavone), a citrus flavonoid, can be used as an anti-inflammatory …

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Z Sun, K Liu, C Liang, L Wen, J Wu… - Phytotherapy …, 2024 - Wiley Online Library
Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other
plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer …

Comparative study of linear polyglycidol acylhydrazones and curcumin conjugates: Surface activity and targeted antitumor drug delivery

Q Chen, Z Liu, H Dai, J Wang, Z Cai, H Zhang… - Colloids and Surfaces A …, 2024 - Elsevier
Linear polyglycidol (LPG) has emerged as a polyethylene glycol (PEG) alternative in novel
surfactant development due to its unique advantages, such as high bioavailability and …

Preparation, characterisation, and pharmacodynamic study of myricetin pH-sensitive liposomes

C Li, M Du, L Meng, M Adu-Frimpong… - Journal of …, 2024 - Taylor & Francis
Aims Myricetin (MYR) was incorporated into pH-sensitive liposomes in order to improve its
bioavailability and anti-hyperuricemic activity. Methods The MYR pH-sensitive liposomes …

HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro‐in vivo Evaluation

Y Zhu, H Wang, M Adu‐Frimpong, Z Zou, Z Jin… - …, 2024 - Wiley Online Library
In this paper, hydroxylapatite (HA) nanoparticles were constructed through the ultrasound‐
assisted dispersion method. Using scanning electron microscopy (SEM), we studied the …