The primary pathophysiological event in the erythrocytes of individuals with the various
sickle syndromes is the intracellular aggregation or polymerization of sickle haemoglobin …

Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …

Antisickling activities of two ethnomedicinal plant recipes used for the management of sickle
cell anaemia in Ibadan, Nigeria Page 1 African Journal of Biotechnology Vol. 8 (1), pp. 020-025 …

The advent of direct binding assays for studying the interactions of immunoglobulins and
antigens has made it important to distinguish among several types of crossreactivity. The …

The primary pathophysiological event in sickling is the intracellular polymerization of
deoxygenated haemoglobin S. Tucaresol (589C80; 4 [2‐formyl‐3‐hydroxy‐phenoxymethyl] …

Several aromatic compounds have been found to inhibit the gelling of sickle cell
hemoglobin. We have tried to correlate the antigelling activity of such compounds with the …

Sickle Cell Anemia and Related Hemoglobinopathies Page 1 Sickle Cell Anemia and Related
Hemoglobinopathies Elliott P. Vichinsky, MD,* and Bertram H. Lubin, MDt SICKLE CELL …

Since 1910 when sickle cell disease was first reported by Dr. James Herrick and the
subsequent characterization by Linus Pauling who hypothesized on the nature of sickle cell …

Purpose: Retinal vascular occlusions in sickle cell anemia patients cause tissue ischemia
and the release of angiogenic mediators that promote the development of retinal …

Sickle cell disease, caused by a mutation in the β-hemoglobin gene, is a Mendelian disorder
with a very diverse phenotype. The primary cause of disease pathophysiology is the …