In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …

Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple
human tumours and functions as a transporter importing cystine for glutathione biosynthesis …

Membraneless organelles involved in RNA processing are biomolecular condensates
assembled by phase separation. Despite the important role of intrinsically disordered protein …

Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the
abundance of which can affect the decoding rate and translation efficiency. To determine …

mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …

Messenger RNA (mRNA) translation by the ribosome represents the final step of a
complicated molecular dance from DNA to protein. Although classically considered a …

Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …