The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

Despite achieving optimal initial responses to androgen deprivation therapy, most patients
with prostate cancer eventually progress to a poor prognosis state known as castration …

Increasing evidence points towards a causal link between exposure to persistent organic
pollutants (POPs) with increased incidence and aggressivity of various cancers. Among …

Colorectal cancer (CRC) ranks third in incidence and second in mortality worldwide.
Metabolic disorders are known to be closely associated with CRC. Functional metabolomics …

Purpose: Develop and deploy a robust discovery platform that encompasses heterogeneity,
clinical annotation, and molecular characterization and overcomes the limited availability of …

Data collected from large-scale studies has shown that the incidence of prostate cancer
globally is on the rise, which could be attributed to an overall increase in lifespan. So, the …

Androgen deprivation therapy is a common treatment method for metastatic prostate cancer
through lowering androgen levels; however, this therapy frequently leads to the …

Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease due to the
absence of effective therapies. A more comprehensive understanding of molecular events …

Simple Summary Almost 90% of prostate cancer metastases occur in bone. The arrival of
tumor cells to the homing organ requires a metabolic adaptation to different nutrients and …

Prostate cancer (PCa) is the most common cancer in men in the western world, but the lack
of specific and sensitive markers often leads to overtreatment of prostate cancer which …