For the past decade, the number of molecular targets for approved drugs has been debated.
Here, we reconcile apparently contradictory previous reports into a comprehensive survey …

The drug discovery process starts with identification of a disease-modifying target. This
critical step traditionally begins with manual investigation of scientific literature and …

Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

Abstract Knowledge of therapeutic targets and early drug candidates is useful for improved
drug discovery. In particular, information about target regulators and the patented …

Extensive efforts have been directed at the discovery, investigation and clinical monitoring of
targeted therapeutics. These efforts may be facilitated by the convenient access of the …

Cheminformatics has main research factors due to increasing size of the search space of
chemical compound databases and the importance of similarity measurements for drug …

Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

Extensive drug discovery efforts have yielded many approved and candidate drugs targeting
various targets in different biological pathways. Several freely accessible databases provide …

Predicting druggability and prioritizing certain disease modifying targets for the drug
development process is of high practical relevance in pharmaceutical research …

Abstract Knowledge and investigation of therapeutic targets (responsible for drug efficacy)
and the targeted drugs facilitate target and drug discovery and validation. Therapeutic …