The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The advent of human induced pluripotent stem cells (iPSCs) presents unprecedented
opportunities to model human diseases. Differentiated cells derived from iPSCs in two …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

Molecular diagnostics provide a powerful method to detect and diagnose various
neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of …

Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Biomarker research in Parkinson's disease (PD) has long been dominated by measuring
dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do …

Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …

Lysosomes are specialized organelles with an acidic pH that act as recycling hubs for
intracellular and extracellular components. They harbour numerous different hydrolytic …

Neurodegenerative diseases are highly debilitating conditions characterised primarily by
progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) …