Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

C Tan, Q Yan, Y Ma, J Fang, Y Yang - Frontiers in Neurology, 2022 - frontiersin.org
Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

[HTML][HTML] The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

A Varesi, LIM Campagnoli, S Chirumbolo… - Pharmacological …, 2023 - Elsevier
Depression is the most prevalent mental disorder in the world associated with huge socio-
economic consequences. While depressive-related symptoms are well known, the …

Neuroinflammation through the vagus nerve-dependent gut–microbiota–brain axis in treatment-resistant depression

K Hashimoto - Progress in Brain Research, 2023 - Elsevier
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

S Hamamah, R Gheorghita, A Lobiuc, IO Sirbu… - Frontiers in …, 2022 - frontiersin.org
Fecal microbiota transplant (FMT) is a therapeutic method that aims to restore normal gut
microbial composition in recipients. Currently, FMT is approved in the USA to treat recurrent …

Anxiolytic-and antidepressant-like effects of Bacillus coagulans Unique IS-2 mediate via reshaping of microbiome gut-brain axis in rats

S Satti, MSK Palepu, AA Singh, Y Jaiswal… - Neurochemistry …, 2023 - Elsevier
Background Due to the rising cases of treatment-refractory affective disorders, the discovery
of newer therapeutic approaches is needed. In recent times, probiotics have garnered …

The microbiota–gut–brain axis and its modulation in the therapy of depression: Comparison of efficacy of conventional drugs and traditional Chinese medicine …

C Bi, S Guo, S Hu, J Chen, M Ye, Z Liu - Pharmacological Research, 2022 - Elsevier
Depression is a common and severe mental disease that places a heavy burden on human
society, which can lead to decreased cognitive function, energy loss, insomnia, and even …

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

A Luqman, A Hassan, M Ullah, S Naseem… - Frontiers in …, 2024 - frontiersin.org
The gut microbiome is a heterogeneous population of microbes comprising viruses,
bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium …

Fecal microbiota transplantation and other gut microbiota manipulation strategies

G Quaranta, A Guarnaccia, G Fancello, C Agrillo… - Microorganisms, 2022 - mdpi.com
The gut microbiota is composed of bacteria, archaea, phages, and protozoa. It is now well
known that their mutual interactions and metabolism influence host organism …