IgA nephropathy (IgAN) is being recognized increasingly as a common form of
glomerulonephritis with progressive potential (17, 29, 42). Our initial goal here is briefly to …

The detection of coeliac disease (CD) remains a challenge to physicians. The classic
textbook pictures of cachectic coeliac patients are entirely misleading. Over the past years it …

OBJECTIVES: Despite some reports on an association between celiac disease and IgA
nephropathy, the evidence is still sparse. Celiac disease is strongly associated with the HLA …

AIMS--To study immune deposits in renal glomeruli. METHODS--Tissue was obtained from
756 necropsy cases from people who had committed suicide or met with a violent death …

This review aimed to capture the key findings that animal models have provided around the
role of the alternative pathway and amplification loop (AP/AL) in disease. Animal models …

Discussion DR. STEVEN N. EMANCIPATOR (Pathologist, University Hos-pitals of
Cleveland, and Associate Professor of Pathology, Case Western Reserve University School …

Abstract IgA Nephropathy (IgAN) is the main cause of primary glomerulonephritis, globally.
This disease is associated with a wide range of clinical presentations, variable prognosis …

In antibody-mediated glomerular disease, deposits of C3 (C3b) are common and are
degraded by factor I to C3c and C3d. However, the kinetics of C3b degradation in …

The autoantigen (s) that we have previously described in human glomeruli, recognized in
IgA nephropathy, has (have) been identified as mesangial cell in origin. Cultured mesangial …

Oral tolerance, an important feature of the mucosal immune system, appears to protect
against immune-mediated disease by blunting production of systemic IgG and IgM antibody …