Results In both studies, positive associations were found between uromodulin and urinary
sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …

Blood pressure (BP) is a complex trait regulated by an intricate network of physiological
pathways involving extracellular fluid volume homeostasis, cardiac contractility and vascular …

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal
epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly …

Among the environmental factors that affect blood pressure, dietary sodium chloride has
been studied the most, and there is general consensus that increased sodium chloride …

Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the
development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract …

High blood pressure is a major contributor to the global burden of disease and discovering
novel causal pathways of blood pressure regulation has been challenging. We tested blood …

More than 800 million people in the world suffer from chronic kidney disease (CKD).
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …

Hypertension is a significant and increasing global health issue. It is a leading cause of
cardiovascular disease and premature death worldwide due to its effects on end organs …