[HTML][HTML] Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases
Y Li, Y Cheng, F Consolato, G Schiano, MR Chong… - JCI insight, 2022 - ncbi.nlm.nih.gov
Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney
disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and …
disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and …
Learning physiology from inherited kidney disorders
J van der Wijst, H Belge, RJM Bindels… - Physiological …, 2019 - journals.physiology.org
The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …
molecular basis of disease and improved our understanding of physiological processes that …
[HTML][HTML] Renal allograft fibrosis: biology and therapeutic targets
Renal tubulointerstitial fibrosis is the final common pathway of progressive renal diseases. In
allografts, it is assessed with tubular atrophy as interstitial fibrosis/tubular atrophy (IF/TA) …
allografts, it is assessed with tubular atrophy as interstitial fibrosis/tubular atrophy (IF/TA) …
The value of uromodulin as a new serum marker to predict decline in renal function
A Leiherer, A Muendlein, CH Saely… - Journal of …, 2018 - journals.lww.com
Background: Uromodulin is the most abundant protein in urine. Low uromodulin has been
found associated with diabetes as well as with chronic kidney disease (CKD). Whether it …
found associated with diabetes as well as with chronic kidney disease (CKD). Whether it …
A structured interdomain linker directs self-polymerization of human uromodulin
M Bokhove, K Nishimura, M Brunati… - Proceedings of the …, 2016 - National Acad Sciences
Uromodulin (UMOD)/Tamm–Horsfall protein, the most abundant human urinary protein,
plays a key role in chronic kidney diseases and is a promising therapeutic target for …
plays a key role in chronic kidney diseases and is a promising therapeutic target for …
Hypertension: Current trends and future perspectives
PG Hunter, FA Chapman… - British Journal of Clinical …, 2021 - Wiley Online Library
Hypertension is a significant and increasing global health issue. It is a leading cause of
cardiovascular disease and premature death worldwide due to its effects on end organs …
cardiovascular disease and premature death worldwide due to its effects on end organs …
Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity
More than 800 million people in the world suffer from chronic kidney disease (CKD).
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
KA LaFavers, E Macedo, PS Garimella… - Science translational …, 2019 - science.org
High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein
(THP)] have recently been shown to be independently associated with low mortality in both …
(THP)] have recently been shown to be independently associated with low mortality in both …
Genetic-variation-driven gene-expression changes highlight genes with important functions for kidney disease
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …
10% of the US population. Genome-wide association studies (GWASs) have identified …
UMOD and the architecture of kidney disease
The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …