β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

J Dai, W Dan, U Schneider, J Wang - European Journal of Medicinal …, 2018 - Elsevier
Abstract β-Carboline alkaloids are a family of natural and synthetic products with great
structural diversity and outstanding biological activities. This review covers critically …

A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective

J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

W Liu, X Liu, L Tian, Y Gao, W Liu, H Chen… - European Journal of …, 2021 - Elsevier
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease,
characterized by irreversible cognitive impairment, memory loss and behavioral …

Directed evolution of RebH for site‐selective halogenation of large biologically active molecules

JT Payne, CB Poor, JC Lewis - Angewandte Chemie, 2015 - Wiley Online Library
We recently characterized the substrate scope of wild‐type RebH and proceeded to evolve
variants of this enzyme with improved stability for biocatalysis. The substrate scopes of both …

Discovery of β-carboline oxadiazole derivatives as fungicidal agents against rice sheath blight

ZJ Zhang, ZY Jiang, Q Zhu… - Journal of agricultural and …, 2018 - ACS Publications
A series of β-carboline oxadiazoles were synthesized, and their fungicidal activities and
mechanism of action against rice sheath blight caused by Rhizoctonia solani was evaluated …

Antibacterial functions and proposed modes of action of novel 1, 2, 3, 4-tetrahydro-β-carboline derivatives that possess an attractive 1, 3-diaminopropan-2-ol pattern …

HW Liu, QT Ji, GG Ren, F Wang, F Su… - Journal of Agricultural …, 2020 - ACS Publications
In recent years, naturally occurring tetrahydro-β-carboline (THC) alkaloids and their
derivatives have been of biological interest. However, few studies and developments have …

Simultaneous production of psilocybin and a cocktail of β‐carboline monoamine oxidase inhibitors in “magic” mushrooms

F Blei, S Dörner, J Fricke, F Baldeweg… - … A European Journal, 2020 - Wiley Online Library
The psychotropic effects of Psilocybe “magic” mushrooms are caused by the l‐tryptophan‐
derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these …

Synthesis of novel antiviral ferulic acid–eugenol and isoeugenol hybrids using various link reactions

X Gan, Z Wang, D Hu - Journal of Agricultural and Food Chemistry, 2021 - ACS Publications
To develop novel antiviral agents, some novel conjugates between ferulic acid and eugenol
or isoeugenol were designed and synthesized by the link reaction. The antiviral activities of …

An overview on synthetic entries to tetrahydro-β-carbolines

P Maity, D Adhikari, AK Jana - Tetrahedron, 2019 - Elsevier
The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

Novel trans-Ferulic Acid Derivatives Containing a Chalcone Moiety as Potential Activator for Plant Resistance Induction

X Gan, D Hu, Y Wang, L Yu, B Song - Journal of Agricultural and …, 2017 - ACS Publications
A series of novel trans-ferulic acid derivatives containing a chalcone moiety were designed
and synthesized to induce plant resistance. Antiviral activities of the compounds were …