BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …

Lipids play a central role in many infectious diseases. AIDS (Acquired Immune Deficiency
Syndrome) and tuberculosis are two of the deadliest infectious diseases to have struck …

Objectives: HIV reservoir in the brain represents a major barrier for curing HIV infection. As
the most abundant, long-lived cell type, astrocytes play a critical role in maintaining the …

Summary Background The CCR5 (R5) to CXCR4 (X4) coreceptor switch in natural HIV-1
infection is associated with faster progression to AIDS, but the mechanisms remain unclear …

Background Human immunodeficiency virus type 1 (HIV-1) clades and clusters have
different epidemic patterns and phenotypic profiles. It is unclear if they also affect patients' …

Chemokines are cytokines whose primary role is cellular activation and stimulation of
leukocyte migration. They perform their various functions by interacting with G protein …

Studies have shown that podocytes and renal tubular epithelial cells from patients with HIV-
associated nephropathy (HIVAN) express HIV-1 transcripts, suggesting that productive …

Background. In the absence of therapy, CXCR4 (X4)–tropic human immunodeficiency virus
type 1 (HIV-1) increases over time, associated with accelerated disease progression. In …

Detailed clonal phenotypic/genotypic analyses explored viral-escape mechanisms during
maraviroc-based therapy in highly treatment-experienced participants from the MOTIVATE …

Interactions between human immunodeficiency virus type 1 (HIV-1) and the host factors or
restriction factors of its target cells determine the cell's susceptibility to, and outcome of …