Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma

Y Qin, X Zheng, W Gao, B Wang, Y Wu - Molecular Therapy-Oncolytics, 2021 - cell.com
Head and neck squamous cell carcinomas (HNSCCs) are a type of common malignant
tumor, mainly manifesting as oropharyngeal, oral cavity, laryngopharyngeal …

The head and neck squamous cell carcinoma microenvironment as a potential target for cancer therapy

J Plzák, J Bouček, V Bandúrová, M Kolář, M Hradilová… - Cancers, 2019 - mdpi.com
Similarly to other types of malignant tumours, the incidence of head and neck cancer is
increasing globally. It is frequently associated with smoking and alcohol abuse, and in a …

Salivary exosomal MicroRNA-486-5p and MicroRNA-10b-5p in oral and oropharyngeal squamous cell carcinoma

CI Faur, RC Roman, A Jurj, L Raduly, O Almășan… - Medicina, 2022 - mdpi.com
Background and Objectives: The research aimed at evaluating the capacity of salivary
exosomal miR-10b-5p and miR-486-5p for oral and oropharyngeal cancer detection …

Boron neutron capture therapy at the crossroads-Where do we go from here?

RF Barth, JC Grecula - Applied Radiation and Isotopes, 2020 - Elsevier
As elegant as is the concept upon which Boron Neutron Capture Therapy (BNCT) is based,
unfortunately it has not gained widespread acceptance by the physicians who are treating …

Prognostic nutritional index for predicting the clinical outcomes of patients with gastric cancer who received immune checkpoint inhibitors

H Sun, L Chen, R Huang, H Pan, Y Zuo, R Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective Although the application of immunotherapy in gastric cancer has achieved
satisfactory clinical effects, many patients have no response. The aim of this retrospective …

Prognostic value of 18F-FDG PET/CT-based radiomics combining dosiomics and dose volume histogram for head and neck cancer

B Wang, J Liu, X Zhang, Z Wang, Z Cao, L Lu, W Lv… - EJNMMI research, 2023 - Springer
Objectives By comparing the prognostic performance of 18F-FDG PET/CT-based radiomics
combining dose features [Includes Dosiomics feature and the dose volume histogram (DVH) …

A new detection method of oral and oropharyngeal squamous cell carcinoma based on multivariate analysis of surface enhanced raman spectra of salivary exosomes

CI Faur, C Dinu, V Toma, A Jurj, R Mărginean… - Journal of Personalized …, 2023 - mdpi.com
Raman spectroscopy recently proved a tremendous capacity to identify disease-specific
markers in various (bio) samples being a non-invasive, rapid, and reliable method for cancer …

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

L de Vos, I Grünwald, EG Bawden, J Dietrich… - Epigenetics, 2020 - Taylor & Francis
ABSTRACT CTLA-4 blocking therapeutic antibodies are currently under investigation in
head and neck squamous cell carcinoma (HNSCC). A better understanding of the …

Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review

CI Faur, H Rotaru, C Osan, A Jurj, RC Roman… - Maxillofacial Plastic and …, 2021 - Springer
Background MicroRNAs (miRs) are small, non-coding mRNA molecules which regulate
cellular processes in tumorigenesis. miRs were discovered in extracellular environment and …

Whole exome sequencing uncovers HRAS mutations as potential mediators of resistance to metronomic chemotherapy

J Sambath, V Noronha, SS Manda, R Mishra… - Gene, 2024 - Elsevier
Objectives The aim of this pilot study is to identify the genetic factors that contribute to the
response of metronomic chemotherapy in head and neck squamous cell carcinoma …