The innate immune system is critical for inducing durable and protective T cell responses to
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …

Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …

The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

Regulatory T (Treg) cells induce an immunosuppressive microenvironment that is a major
obstacle for successful tumor immunotherapy. Dissecting the regulatory mechanisms …

Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …

Adoptive immunotherapy with T cells expressing chimeric antigen receptors (CAR) has had
limited success for solid tumors in early-phase clinical studies. We reasoned that introducing …

Upon infection, CD8+ T cells undergo a stepwise process of early activation, expansion, and
differentiation into effector cells. How these phases are transcriptionally regulated is …

T cell responses are essential for appropriate protection against pathogens. T cell immunity
is achieved through the ability to discriminate between foreign and self-molecules, and this …