Osteoarthritis (OA) is a multifactorial disease contributing to significant disability and
economic burden in Western populations. The aetiology of OA remains poorly understood …

Rationale & Objective While urine excretion of nitrogen estimates the total protein intake,
biomarkers of specific dietary protein sources have been sparsely studied. Using untargeted …

Metabolomics, or biochemical profiling, is closely integrated with genomics and proteomics.
The metabonome is the complete collection of small molecule metabolites or chemicals (< …

Over the past few decades, genomewide association studies (GWASs) have identified the
specific genetics variants contributing to many complex diseases by testing millions of …

Background: Cisplatin, a chemotherapy used to treat solid tumors, causes acute kidney
injury (AKI), a known risk factor for chronic kidney disease and mortality. AKI diagnosis relies …

The idea that alterations in biologic fluids can denote the health status of an individual goes
back to ancient times, and has been a foundation of nephrology practice since its inception …

The prevalence of chronic kidney disease (CKD) is increasing due to the global ageing
trend. Despite significant advancements in understanding the mechanisms of CKD, little …

Renal transplantation is the gold-standard procedure for end-stage renal disease patients,
improving quality of life and life expectancy. Despite continuous advancement in the …

Background Dietary consumption has traditionally been studied through food intake
questionnaires. Metabolomics can be used to identify blood markers of dietary protein that …

In this chapter, a broad history of the field of metabolic phenotyping (also known as
metabonomics and metabolomics) is presented. Largely overlooked pioneering studies from …