Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

SR Protein Kinases (SRPKs), discovered approximately 30 years ago, are widely known as
splice factor kinases due to their decisive involvement in the regulation of various steps of …

Patients with head‐and‐neck cancer can develop both lung metastasis and primary lung
cancer during the course of their disease. Despite the clinical importance of discrimination …

Background Phosphorylation is an important regulatory mechanism of protein activity in
cells. Studies in various cancers have reported perturbations in kinases resulting in aberrant …

Mycobacterium tuberculosis, the causative agent of tuberculosis, accounts for 1.5 million
human deaths annually worldwide. Despite efforts to eradicate tuberculosis, it still remains a …

Labeling peptides with isobaric tags is a popular strategy in quantitative bottom-up
proteomics. In this study, we labeled six breast tumor cell lysates (1.34 mg proteins per …

Carcinogenic effect of tobacco in oral cancer is through chewing and/or smoking. Significant
differences exist in development of oral cancer between tobacco users and non-users …

Cancers have a strong relationship with immune cells in their microenvironment, which
significantly influences tumor proliferation and progression. Thus, pharmacological …

Exposure to arsenic, a class I carcinogen, affects 200 million people globally. Skin is the
major target organ, but the molecular etiology of arsenic-induced skin carcinogenesis …

Signaling pathways driven by protein and lipid kinases are altered in most human diseases.
Therefore, pharmacological inhibitors of cell signaling are one of the most intensively …