Heme-regulated inhibitor (HRI) kinase is a serine–threonine kinase, controlling the initiation
of protein synthesis via phosphorylating α subunit of eIF2 on serine 51 residue, mainly in …

Nanotechnology has been used in many biosensing and medical applications, in the form of
noble metal (gold and silver) nanoparticles and nanostructured substrates. However, the …

Simple Summary Multiple myeloma is the second most common cancer of the blood system
in the US. Despite new therapies, a cure remains elusive, and current drugs inevitably …

Background: The ubiquitin-proteasome pathway is involved in almost all cellular processes
(cell cycle, gene transcription and translation, cell survival and apoptosis, cell metabolism …

Cells encountering stressful situations activate the integrated stress response (ISR) pathway
to limit protein synthesis and redirect translation to better cope. The ISR has also been …

Background Multiple myeloma (MM) is an incurable hematological malignancy. Although
proteasome inhibitors and immunomodulators have significantly improved patient outcomes …

The ubiquitin–proteasome pathway is an important protein quality control system involved in
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …

Background: The ubiquitin-proteasome pathway is crucial for all cellular processes and is,
therefore, a critical target for the investigation and development of novel strategies for cancer …

The effectiveness of proteasome inhibitors against solid tumors is limited as the emergence
of resistance is rapid. Although many mechanisms have been proposed and verified, no …

Objective: Senescence may act as an antitumor mechanism by preventing the proliferation
of cancer cells. Here we investigated the hypothesis that PC3 prostate cancer cells resistant …