Heme-regulated inhibitor: an overlooked EIF2α kinase in cancer investigations
A Yerlikaya - Medical Oncology, 2022 - Springer
Heme-regulated inhibitor (HRI) kinase is a serine–threonine kinase, controlling the initiation
of protein synthesis via phosphorylating α subunit of eIF2 on serine 51 residue, mainly in …
of protein synthesis via phosphorylating α subunit of eIF2 on serine 51 residue, mainly in …
Quantum leap from gold and silver to aluminum nanoplasmonics for enhanced biomedical applications
S Ambardar, D Nguyen, G Binder, ZW Withers… - Applied Sciences, 2020 - mdpi.com
Nanotechnology has been used in many biosensing and medical applications, in the form of
noble metal (gold and silver) nanoparticles and nanostructured substrates. However, the …
noble metal (gold and silver) nanoparticles and nanostructured substrates. However, the …
The mitochondrial protease LonP1 promotes proteasome inhibitor resistance in multiple myeloma
L Maneix, MA Sweeney, S Lee, P Iakova, SE Moree… - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma is the second most common cancer of the blood system
in the US. Despite new therapies, a cure remains elusive, and current drugs inevitably …
in the US. Despite new therapies, a cure remains elusive, and current drugs inevitably …
The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress
Cells encountering stressful situations activate the integrated stress response (ISR) pathway
to limit protein synthesis and redirect translation to better cope. The ISR has also been …
to limit protein synthesis and redirect translation to better cope. The ISR has also been …
The ubiquitin-proteasome pathway and epigenetic modifications in cancer
A Yerlikaya, E Kanbur, BA Stanley… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: The ubiquitin-proteasome pathway is involved in almost all cellular processes
(cell cycle, gene transcription and translation, cell survival and apoptosis, cell metabolism …
(cell cycle, gene transcription and translation, cell survival and apoptosis, cell metabolism …
ZHX2 mediates proteasome inhibitor resistance via regulating nuclear translocation of NF‐κB in multiple myeloma
J Jiang, Y Sun, J Xu, T Xu, Z Xu, P Liu - Cancer Medicine, 2020 - Wiley Online Library
Background Multiple myeloma (MM) is an incurable hematological malignancy. Although
proteasome inhibitors and immunomodulators have significantly improved patient outcomes …
proteasome inhibitors and immunomodulators have significantly improved patient outcomes …
Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line
The ubiquitin–proteasome pathway is an important protein quality control system involved in
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
intracellular homeostasis. To achieve intracellular homeostasis, proteins that are misfolded …
The ubiquitin-proteasome pathway and resistance mechanisms developed against the proteasomal inhibitors in cancer cells
A Yerlikaya, E Kanbur - Current Drug Targets, 2020 - ingentaconnect.com
Background: The ubiquitin-proteasome pathway is crucial for all cellular processes and is,
therefore, a critical target for the investigation and development of novel strategies for cancer …
therefore, a critical target for the investigation and development of novel strategies for cancer …
The ERK1/2-Elk1, JNK-cJun, and JAK-STAT Transcriptional Axes as Potential Bortezomib Resistance Mediators in Prostate Cancer
G Kalampounias, K Zafeiropoulou, T Androutsopoulou… - bioRxiv, 2024 - biorxiv.org
The effectiveness of proteasome inhibitors against solid tumors is limited as the emergence
of resistance is rapid. Although many mechanisms have been proposed and verified, no …
of resistance is rapid. Although many mechanisms have been proposed and verified, no …
The Senescence Program is Reduced in Proteasome Inhibitor Bortezomib-Resistant PC3 Prostate Cancer Cell Line
Objective: Senescence may act as an antitumor mechanism by preventing the proliferation
of cancer cells. Here we investigated the hypothesis that PC3 prostate cancer cells resistant …
of cancer cells. Here we investigated the hypothesis that PC3 prostate cancer cells resistant …