International union of basic and clinical pharmacology. XCII. Urotensin II, urotensin II–related peptide, and their receptor: From structure to function
H Vaudry, J Leprince, D Chatenet, A Fournier… - Pharmacological …, 2015 - ASPET
Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …
Urotensin-II receptor modulators as potential drugs
BE Maryanoff, WA Kinney - Journal of medicinal chemistry, 2010 - ACS Publications
Urotensin-II (U-IIa) represents a series of cyclic peptides ranging in size from 8 to 14 amino
acids across different animal species, from frogs to fish to humans (Figure 1). 1 Amino acid …
acids across different animal species, from frogs to fish to humans (Figure 1). 1 Amino acid …
A novel urotensin II receptor antagonist, KR-36996, improved cardiac function and attenuated cardiac hypertrophy in experimental heart failure
KS Oh, JH Lee, KY Yi, CJ Lim, BK Park, HW Seo… - European journal of …, 2017 - Elsevier
Urotensin II and its receptor are thought to be involved in various cardiovascular diseases
such as heart failure, pulmonary hypertension and atherosclerosis. Since the regulation of …
such as heart failure, pulmonary hypertension and atherosclerosis. Since the regulation of …
[PDF][PDF] The urotensin II receptor antagonist DS37001789 ameliorates mortality in pressure-overload mice with heart failure
M Nishi, H Tagawa, M Ueno, S Marumoto, T Nagayama - Heliyon, 2020 - cell.com
This study was designed to evaluate the effects of DS37001789, a novel and highly potent
urotensin II (U-II) receptor (GPR14) antagonist, against mortality, hypertrophy, and cardiac …
urotensin II (U-II) receptor (GPR14) antagonist, against mortality, hypertrophy, and cardiac …
[HTML][HTML] The efficiency of a urotensin II antagonist in an experimental lung fibrosis model
AM Onat, IH Turkbeyler, Y Pehlivan, T Demir… - Inflammation, 2012 - Springer
Pulmonary fibrosis is a chronic disease. Urotensin II (U-II) is a new peptide with angiogenic
and profibrotic features. Therefore, we aim to evaluate the antagonism of U-II with palosuran …
and profibrotic features. Therefore, we aim to evaluate the antagonism of U-II with palosuran …
Identification of novel Urotensin-II receptor antagonists with potent inhibition of U-II induced pressor response in mice
Abstract Urotensin II (U-II) has been found to be one of the most potent vasoconstrictor
(Ames et al., 1999; Bohm et al., 2002) reported till date. U-II exerts its response via activation …
(Ames et al., 1999; Bohm et al., 2002) reported till date. U-II exerts its response via activation …
Inhibition of U‐II/UT signaling ameliorates cystitis‐associated bladder hyperactivity by targeting the RhoA/Rho‐kinase pathway
Q Liu, QD Lu, BS Sun, J Zhao, F He… - The Kaohsiung Journal …, 2022 - Wiley Online Library
Abstract Urotensin II (U‐II) and its receptor (UT) are involved in the pathogenesis of various
diseases; however, their association with the development of cystitis has not been …
diseases; however, their association with the development of cystitis has not been …
2-{N-[(2, 4, 5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide analogs as potential antagonists of Urotensin II receptor
A Soni, S Saha, A Agarwal… - Journal of Receptors …, 2023 - Taylor & Francis
The purpose of the article To identify novel small molecule antagonists of Urotensin II
receptor with acceptable pharmacological profile. Materials and methods Structure-activity …
receptor with acceptable pharmacological profile. Materials and methods Structure-activity …
Urotensin II contributes to collagen synthesis and up-regulates Egr-1 expression in cultured pulmonary arterial smooth muscle cells through the ERK1/2 pathway
W Li, Z Cai, M Liu, C Zhao, D Li, C Lv, Y Wang… - Biochemical and …, 2015 - Elsevier
Aim The objective of this study was to investigate the effects of urotensin II (UII) treatment on
the proliferation and collagen synthesis of cultured rat pulmonary arterial smooth muscle …
the proliferation and collagen synthesis of cultured rat pulmonary arterial smooth muscle …
Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease
AD Leonard, JP Thompson… - British journal of …, 2009 - academic.oup.com
Abstract Background Urotensin II (UII) and its receptor UT are involved in control of the
cardiovascular system and are implicated in heart failure. We measured UT expression by …
cardiovascular system and are implicated in heart failure. We measured UT expression by …