Accumulating research suggests that the tumor immune microenvironment (TIME) plays an
essential role in regulation of tumor growth and metastasis. The cellular and molecular …

The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-
fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the …

Pancreatic cancer is the fourth-leading cause of cancer-related deaths and is expected to be
the second-leading cause of cancer-related deaths in Europe and the United States by …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-
coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through …

Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play
important roles as gene regulators. Disturbed expressions of circRNAs is closely related to …

Pancreatic cancer is an aggressive disease with poor prognosis. Only about 15–20% of
patients diagnosed with pancreatic cancer can undergo surgical resection, while the …

The alarmingly low five-year survival rate for pancreatic cancer presents a global health
challenge, contributing to about 7% of all cancer-related deaths. Late-stage diagnosis and …

Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in various types of tumors
and functions as an oncogene; it could also be a potential target in tumor therapy …

Simple Summary Pancreatic cancer is an aggressive disease with a high mortality rate.
Radiotherapy is one treatment option within a multimodal therapy approach for patients with …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with especially poor
prognosis. However, the molecular mechanisms of pancreatic oncogenesis and malignant …