Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

The decision to enter mitosis is mediated by a network of proteins that regulate activation of
the cyclin B–Cdk1 complex. Within this network, several positive feedback loops can amplify …

The cell cycle is strictly ordered to ensure faithful genome duplication and chromosome
segregation. Control mechanisms establish this order by dictating when a cell transitions …

Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to
drive cell division. In contrast, mammalian cells are thought to require the sequential …

In the cell cycle, there are two checkpoint arrests that allow cells to repair damaged DNA in
order to maintain genomic integrity. Many cancer cells have defective G1 checkpoint …

CDK1 is the only essential cell cycle CDK in human cells and is required for successful
completion of M-phase. It is the founding member of the CDK family and is conserved across …

The DNA damage response pathways involve processes of double-strand break (DSB)
repair and cell cycle checkpoint control to prevent or limit entry into S phase or mitosis in the …

The 26S proteasome complex engages in an ATP-dependent proteolytic degradation of a
variety of oncoproteins, transcription factors, cell cycle specific cyclins, cyclin-dependent …

Abstract Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the
anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles …

Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor
loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition …