Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

KD Fasae, AO Abolaji - Current opinion in insect science, 2022 - Elsevier
Highlights•Drosophila is a useful model to study interactions of non-essential heavy
metals.•Cd, Pb, and Hg reduce the development of Drosophila.•Cd, Pb, and Hg induce …

Elesclomol, a copper-transporting therapeutic agent targeting mitochondria: from discovery to its novel applications

M Tarin, M Babaie, H Eshghi, MM Matin… - Journal of Translational …, 2023 - Springer
Copper (Cu) is an essential element that is involved in a variety of biochemical processes.
Both deficiency and accumulation of Cu are associated with various diseases; and a high …

Circulating copper levels and the risk of cardio-cerebrovascular diseases and cardiovascular and all-cause mortality: A systematic review and meta-analysis of …

H Zhao, K Mei, Q Hu, Y Wu, Y Xu, P Yu, Y Deng… - Environmental …, 2023 - Elsevier
Background Copper is an essential trace element in the human body; its relationship with
cardio-cerebrovascular diseases (CCVDs) remains unclear. This study aimed to …

Single and combined associations of plasma and urine essential trace elements (Zn, Cu, Se, and Mn) with cardiovascular risk factors in a mediterranean population

R Barragán, C Sánchez-González, P Aranda, JV Sorlí… - Antioxidants, 2022 - mdpi.com
Trace elements are micronutrients that are required in very small quantities through diet but
are crucial for the prevention of acute and chronic diseases. Despite the fact that initial …

The genetic basis of adaptation to copper pollution in Drosophila melanogaster

ER Everman, SJ Macdonald, JK Kelly - Frontiers in Genetics, 2023 - frontiersin.org
Introduction: Heavy metal pollutants can have long lasting negative impacts on ecosystem
health and can shape the evolution of species. The persistent and ubiquitous nature of …

Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster

ER Everman, SJ Macdonald - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
Copper is one of a handful of biologically necessary heavy metals that is also a common
environmental pollutant. Under normal conditions, copper ions are required for many key …

Molecular physiology of copper in drosophila melanogaster

R Burke - Current Opinion in Insect Science, 2022 - Elsevier
Highlights•Novel protein Gawky is required for the metal-induced nuclear translocation of
MTF-1.•Scox is critical for mitochondrial morphogenesis and function in ensheathing …

The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors

L Green, M Coronado-Zamora, S Radío, GE Rech… - BMC biology, 2022 - Springer
Background Escalation in industrialization and anthropogenic activity have resulted in an
increase of pollutants released into the environment. Of these pollutants, heavy metals such …

Alkaloid-rich extract of Buchholzia coriacea seed mitigate the effect of copper-induced toxicity in Drosophila melanogaster

SO Anadozie, AU Aduma, OB Adewale - Vegetos, 2024 - Springer
Buchholzia coriacea is known for its anti-oxidative, anti-inflammatory, and anti-diabetic
properties. This study evaluated the effect of alkaloid-rich extract of Buchholzia coriacea …

The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster

BR Smith, KB Patch, A Gupta, EM Knoles… - PLoS …, 2023 - journals.plos.org
The genetic causes of phenotypic variation often differ depending on the population
examined, particularly if the populations were founded by relatively small numbers of …