RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Structurally diverse pyridinium salts are quite familiar structures in many natural products
and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played …

A key end goal of gene delivery research is to develop clinically relevant vectors that can be
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …

The development of novel antimicrobial agents having high selectivity toward bacterial cells
over mammalian cells is urgently required to curb the widespread emergence of infectious …

Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and
RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the …

This feature article describes the recent developments in the design of cationic lipids and
their applications in gene delivery. Various structure–activity investigations explaining the …

Three different sets of cationic surfactants from lysine have been synthesized. The first group
consists of three monocatenary surfactants with one lysine as the cationic polar head with …

Geminicationic surfactants are compounds which are composed of two hydrophilic head
groups and two hydrophobic tails linked by a spacer at the head groups or closed to them …