Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission

D Stolz, T Mkorombindo, DM Schumann, A Agusti… - The Lancet, 2022 - thelancet.com
Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

Nonantimicrobial actions of macrolides: overview and perspectives for future development

JA Kricker, CP Page, FR Gardarsson… - Pharmacological …, 2021 - ASPET
Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly
for respiratory infections. It is now recognized that these drugs, in particular azithromycin …

Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials

M Bafadhel, S Peterson, MA De Blas… - The Lancet …, 2018 - thelancet.com
Background The peripheral blood eosinophil count might help identify those patients with
chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations …

Inflammatory endotypes in COPD

PJ Barnes - Allergy, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

P Paliogiannis, AG Fois, S Sotgia… - European …, 2018 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised
by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a …

Withdrawal of inhaled corticosteroids in COPD: a European Respiratory Society guideline

JD Chalmers, IF Laska, FME Franssen… - European …, 2020 - Eur Respiratory Soc
Inhaled corticosteroids (ICS) combined with bronchodilators can reduce the frequency of
exacerbations in some patients with chronic obstructive pulmonary disease (COPD). There …

Comparative effectiveness of LABA-ICS versus LAMA as initial treatment in COPD targeted by blood eosinophils: a population-based cohort study

S Suissa, S Dell'Aniello, P Ernst - The Lancet Respiratory Medicine, 2018 - thelancet.com
Background Long-acting β 2 agonists (LABAs) and long-acting muscarinic antagonists
(LAMAs) are the recommended initial maintenance treatment for chronic obstructive …

Comparative effectiveness and safety of LABA-LAMA vs LABA-ICS treatment of COPD in real-world clinical practice

S Suissa, S Dell'Aniello, P Ernst - Chest, 2019 - Elsevier
Background Long-acting β 2-agonists (LABAs) and long-acting muscarinic antagonists
(LAMAs) are recommended as initial maintenance treatments for COPD, with their …

Comparative effects of LAMA-LABA-ICS vs LAMA-LABA for COPD: cohort study in real-world clinical practice

S Suissa, S Dell'Aniello, P Ernst - Chest, 2020 - Elsevier
Background Triple therapy combinations of a long-acting muscarinic antagonist (LAMA), a
long-acting beta 2-agonist (LABA), and an inhaled corticosteroid (ICS) for COPD were …

[PDF][PDF] Making sense of triple inhaled therapy for COPD

S Suissa, JM Drazen - N Engl J Med, 2018 - ti.ubc.ca
Guidelines for the treatment of chronic obstructive pulmonary disease (COPD) have
consistently recommended long-acting inhaled bronchodilators—either long-acting …